We engineer a brane picture for the reduction of Seiberg dualities from four dimensions to three dimensions, valid also in the presence of orientifold planes. We obtain effective three-dimensional dualities on the circle by T-duality, geometrizing the non-perturbative superpotential which is an affine Toda potential. When reducing to pure three dimensions, we define a double-scaling limit which creates a confining sector, giving a unified mechanism for the brane reduction of dualities.